News from our Labs

Tishina S, Dahlhaus A, Manik M, Mulalic L, Murr J, Kotliar M, Rakhsh-Khorshid H, Kostopoulou M, Hocher F, Stroh J, Beck J, Williams RM, Balta GG, Liu F, Abdallah AT, Bebber CM, Reese M, Lim JKM, Quaas A, Brägelmann J, Pasparakis M, Beleggia F, Balachandran S, Trauzold A, Liccardi G, Astsaturov I, Reichert M, Androulidaki A, von Karstedt S. Oncogenic KRAS-driven type I interferon signalling primes pancreatic cancer for necroptosis. Nat Commun. 2026 Jun 15;17(1):5288. doi: 10.1038/s41467-026-73189-8. PMID: 42297776; 
PMCID: PMC13269921.

Werr L, Boland J, Petersen J, Iglesias F, Höppner S, Bartenhagen C, Rosswog C, Hellmann AM, Kahlert Y, Hemstedt N, Ibruli N, Dammert MA, Decarolis B, Werner JM, Malchers F, Schramm K, Witt O, Beiske KH, Rognlien AGW, Gunnes MW, Langenberg KP, Molenaar J, Bernkopf M, Taschner-Mandl S, Hughes D, George SL, Chesler L, Schulte JH, Barone G, Capasso M, Surrey LF, Bagatell R, Masliah-Planchon J, Schleiermacher G, Grüll H, Westermann F, Schultheis AM, Büttner R, Henssen AG, Eggert A, Peifer M, Shukla NN, Simon T, Hero B, Reinhardt HC, Thomas RK, Fischer M. Mutated FGFR1 is an oncogenic driver and therapeutic target in high-risk neuroblastoma. J Clin Invest. 2026 Feb 12;136(7):e189152. doi: 10.1172/JCI189152. PMID: 41678281; 
PMCID: PMC13038208.

Höppner S, Werr L, Szilagyi B, Bartenhagen C, Hellmann AM, Rosswog C, Linden E, Primke G, Kahlert Y, Ibruli N, Hemstedt N, Lorenz W, Brägelmann J, Hölzel M, Fischer M. Telomere damage enhances immunogenicity of neuroblastoma and accelerates response to anti-PD-L1 treatment. Oncoimmunology. 2026 Dec 31;15(1):2653918. doi: 10.1080/2162402X.2026.2653918. Epub 2026 Apr 8. 
PMID: 41948996.

Androulidaki A, Liu F, Bebber CM, Kisis I, Sakthivelu V, Hunold P, Koerner L, Dahlhaus A, Yapici FI, Grimm C, Pacholewska A, Tishina S, Doskotz F, Torres Fernández LA, Stroh J, Abdallah AT, Beck J, Mulalic L, Schmitt A, Grüll H, Persigehl T, Quaas A, Peifer M, Brägelmann J, Reinhardt HC, Nieper P, Hänsel-Hertsch R, Thomas RK, George J, Schweiger MR, Pasparakis M, Beleggia F, von Karstedt S. Lack of caspase 8 directs neuronal progenitor-like reprogramming and small cell lung cancer progression. Nat Commun. 2025 Dec 18;16(1):11280. doi: 10.1038/s41467-025-67142-4. PMID: 41413044; PMCID: PMC12717127.

Sakthivelu V, Schmitt A, Odenthal F, Ndoci K, Touet M, Shaib AH, Chihab A, Wani GA, Nieper P, Hartmann GG, Pintelon I, Kisis I, Boecker M, Eckert NM, Ianicelli Caiaffa M, Ibruli O, Weber J, Maresch R, Bebber CM, Chitsaz A, Lütz A, Kim Alves Carpinteiro M, Morris KM, Franchino CA, Benz J, Pérez-Revuelta L, Soriano-Campos JA, Huetzen MA, Goergens J, Jevtic M, Jahn-Kelleter HM, Zempel H, Placzek A, Hennrich AA, Conzelmann KK, Tumbrink HL, Hunold P, Isensee J, Werr L, Gaedke F, Schauss A, Minère M, Müller M, Fenselau H, Liu Y, Heimsoeth A, Gülcüler Balta GS, Walczak H, Frezza C, Jachimowicz RD, George J, Schmiel M, Brägelmann J, Hucho T, von Karstedt S, Peifer M, Annibaldi A, Hänsel-Hertsch R, Persigehl T, Grüll H, Sos ML, Reifenberger G, Fischer M, Adriaensen D, Büttner R, Sage J, Brouns I, Rad R, Thomas RK, Anstötz M, Rizzoli SO, Bergami M, Motori E, Reinhardt HC, Beleggia F. Functional synapses between neurons and small cell lung cancer. Nature. 2025 Sep 10. doi: 10.1038/s41586-025-09434-9. PMID: 40931078.

Rose F, Ibruli O, Lichius L, Kiljan M, Gozum G, Caiaffa MI, Cai J, Niu LN, Herter JM, Grüll H, Büttner R, Beleggia F, Bosco G, George J, Herter-Sprie GS, Reinhardt HC, Bozek K. Imaging mass cytometry dataset of small-cell lung cancer tumors and tumor microenvironments. BMC Res Notes. 2025 Sep 8;18(1):385. doi: 10.1186/s13104-025-07460-4. PMID: 40922010; PMCID: PMC12418687.

Kelepouras K, Saggau J, Bonasera D, Kiefer C, Locci F, Rakhsh-Khorshid H, Grauvogel L, Varanda AB, Peifer M, Loricchio E, Montinaro A, Croon M, Trifunovic A, Prencipe G, Insalaco A, De Benedetti F, Walczak H, Liccardi G. STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD. Nature. 2025 Aug 20. doi: 10.1038/s41586-025-09536-4. Epub ahead of print. PMID: 40834903.

Hunold P, Pizzolato G, Heramvand N, Kaiser L, Barbiera G, van Ray O, Thomas R, George J, Peifer M, Hänsel-Hertsch R. DynaTag for efficient mapping of transcription factors in low-input samples and at single-cell resolution. Nat Commun. 2025 Jul 28;16(1):6585. doi: 10.1038/s41467-025-61797-9. PMID: 40721574; PMCID: PMC12304361.

Pisula JI, Helbig D, Sancéré L, Persa OD, Bürger C, Fröhlich A, Lorenz C, Bingmann S, Niebel D, Drexler K, Landsberg J, Thomas R, Bozek K, Brägelmann J. Explainable, federated deep learning model predicts disease progression risk of cutaneous squamous cell carcinoma. NPJ Precis Oncol. 2025 Jun 28;9(1):205. doi: 10.1038/s41698-025-00997-4. PMID: 40581685; PMCID: PMC12206231.

Stahl D, Gödel P, Balke-Want H, Gholamipoorfard R, Segbers P, Tetenborg L, Koker M, Dörr J, Gregor L, Bachurski D, Rose F, Simon AG, Good Z, Jakob J, Häupl B, Nill M, Flümann R, Riet T, Lange D, Blakemore SJ, Baurmann H, Voltin CA, Potter N, Schlözer L, Freihammer M, Wagener-Ryczek S, Iuga AI, Heger JM, Ludwig H, Schleifenbaum JK, Propp J, Bröckelmann PJ, Jachimowicz RD, Knittel G, Borchmann S, Merkelbach-Bruse S, Pallasch C, Peifer M, Rybniker J, Quaas A, Nitz M, Brägelmann J, Müller W, Persigehl T, Bozek K, Theobald SJ, Büttner R, Oellerich T, Hallek M, Kobold S, Chmielewski M, Reinhardt HC, Mackall C, Abedpour N, Borchmann P, Ullrich RT. CSF1R⁺ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma. Cancer Cell. 2025 Jun 10:S1535-6108(25)00222-3. doi: 10.1016/j.ccell.2025.05.013. Epub ahead of print. PMID: 40513575.

Gewalt T, Dmitrieva AM, Elsner F, Zhao X, Sieber DD, Kocak IG, Yang Q, Orschel CV, Eckert NM, Goebel B, Nill M, Peter F, Hartmann A, Beleggia F, Odenthal M, Reinhardt HC, Ullrich RT, Graw F, Meder L. TAT-CRE inhalation enables tumor induction corresponding to adenoviral Cre-recombinase in a lung cancer mouse model. Commun Biol. 2025 May 13;8(1):741. doi: 10.1038/s42003-025-08146-0. PMID: 40360735; PMCID: PMC12075843.

Stachura P, Lu Z, Kronberg RM, Xu HC, Liu W, Tu JW, Schaal K, Kameri E, Picard D, von Karstedt S, Fischer U, Bhatia S, Lang PA, Borkhardt A, Pandyra AA. Deep transfer learning approach for automated cell death classification reveals novel ferroptosis-inducing agents in subsets of B-ALL. Cell Death Dis. 2025 May 18;16(1):396. doi: 10.1038/s41419-025-07704-y. PMID: 40382332; PMCID: PMC12085637.

Spindler J, Pandolfo F, Koch AE, Piccirillo P, Bihler J, Morgenstern M, Buschbaum S, Coon J, Hänsel-Hertsch R, Mehta KPM, Panier S. SLX4IP acts in parallel to FANCM to limit BLM-dependent replication stress at ALT telomeres. bioRxiv [Preprint]. 2025 May 29:2025.05.28.656696. doi: 10.1101/2025.05.28.656696. PMID: 40501906; PMCID: PMC12154878.

Roeck BF, Lotfipour Nasudivar S, Vorndran MRH, Schueller L, Yapici FI, Rübsam M, von Karstedt S, Niessen CM, Garcia-Saez AJ. Ferroptosis spreads to neighboring cells via plasma membrane contacts. Nat Commun. 2025 Mar 26;16(1):2951. doi: 10.1038/s41467-025-58175-w. PMID: 40140422; PMCID: PMC11947162.

Simonis A, Theobald SJ, Koch AE, Mummadavarapu R, Mudler JM, Pouikli A, Göbel U, Acton R, Winter S, Albus A, Holzmann D, Albert MC, Hallek M, Walczak H, Ulas T, Koch M, Tessarz P, Hänsel-Hertsch R, Rybniker J. Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages. Mol Syst Biol. 2025 Apr;21(4):341-360. doi: 10.1038/s44320-025-00093-6. Epub 2025 Mar 25. PMID: 40133533; PMCID: PMC11965535.

Yapici FI, Seidel E, Dahlhaus A, Weber J, Schmidt C, de Britto Chaves Filho A, Yang M, Nenchova M, Güngör E, Stroh J, Kotouza I, Beck J, Abdallah AT, Lackmann JW, Bebber CM, Androulidaki A, Kreuzaler P, Schulze A, Frezza C, von Karstedt S. An atlas of ferroptosis-induced secretomes. Cell Death Differ. 2025 Apr 25. doi: 10.1038/s41418-025-01517-4. Epub ahead of print. PMID: 40281125.

Frobel J, Hänsel-Hertsch R. The age-related decline of helicase function-how G-quadruplex structures promote genome instability. FEBS Lett. 2025 Jan;599(2):267-274. doi: 10.1002/1873-3468.14939. Epub 2024 May 27. PMID: 38803008; PMCID: PMC11771695.

Pedrera L, Prieto Clemente L, Dahlhaus A, Lotfipour Nasudivar S, Tishina S, Olmo González D, Stroh J, Yapici FI, Singh RP, Grotehans N, Langer T, García-Sáez AJ, von Karstedt S. Ferroptosis triggers mitochondrial fragmentation via Drp1 activation. Cell Death Dis. 2025 Jan 25;16(1):40. doi: 10.1038/s41419-024-07312-2. PMID: 39863602; PMCID: PMC11762985.