The Research Mission of the Department of Translational Genomics is to understand the impact of somatic genetic alterations in cancer cells on the highly complex regulatory network of signaling pathways. Therefor we link basic research and the application of new findings with translational research to close the loop, linking disciplines and delivering therapies to patients more rapidly.
Our Department is highly interdisciplinary, covering expertise in biochemistry and signaling, structural biology, medicinal chemistry and structure-guided drug design, cancer immunology and inflammation, molecular pathology, mouse models, cancer genomics as well as computational genomics.
We build our Department on a portfolio of established technological platforms, covering approaches involving genomics, immunomics, cellular models, genetically engineered mouse models (GEMMs) and imaging, as well as computational efforts to understand the molecular evolution of cancer. Particular emphasis is placed on carefully interrogating the discoveries made in large scale high-throughput assays in subsequent fine-grained mechanistic experiments. Our scientific efforts are intimately linked to the clinic through a translational platform, which facilitates the longitudinal molecular monitoring of patients, thus providing mechanisms of evolution and adaptation to therapy.
The Department of Translational Genomics was founded on December 1st, 2011 and is chaired by the Director Prof. Roman Thomas. In the last few years, the Department has grown steadily and now comprises 9 different working groups that work closely and interdisciplinary on common research questions.
To maintain a high level of quality, the Department is supported by the Coordination Office. The DTG Coordination Office is responsible for supporting all research groups and for undertaking and delivering long-term strategic administrative planning.
Administrative support is offered to our labs covering all aspects of their working life in order to assist in maintaining excellence in research: grants, day-to-day paperwork, purchase orders, scheduling meetings, travel arrangements, and more.