News from our Labs

Sakthivelu V, Schmitt A, Odenthal F, Ndoci K, Touet M, Shaib AH, Chihab A, Wani GA, Nieper P, Hartmann GG, Pintelon I, Kisis I, Boecker M, Eckert NM, Ianicelli Caiaffa M, Ibruli O, Weber J, Maresch R, Bebber CM, Chitsaz A, Lütz A, Kim Alves Carpinteiro M, Morris KM, Franchino CA, Benz J, Pérez-Revuelta L, Soriano-Campos JA, Huetzen MA, Goergens J, Jevtic M, Jahn-Kelleter HM, Zempel H, Placzek A, Hennrich AA, Conzelmann KK, Tumbrink HL, Hunold P, Isensee J, Werr L, Gaedke F, Schauss A, Minère M, Müller M, Fenselau H, Liu Y, Heimsoeth A, Gülcüler Balta GS, Walczak H, Frezza C, Jachimowicz RD, George J, Schmiel M, Brägelmann J, Hucho T, von Karstedt S, Peifer M, Annibaldi A, Hänsel-Hertsch R, Persigehl T, Grüll H, Sos ML, Reifenberger G, Fischer M, Adriaensen D, Büttner R, Sage J, Brouns I, Rad R, Thomas RK, Anstötz M, Rizzoli SO, Bergami M, Motori E, Reinhardt HC, Beleggia F. Functional synapses between neurons and small cell lung cancer. Nature. 2025 Sep 10. doi: 10.1038/s41586-025-09434-9. PMID: 40931078.

Rose F, Ibruli O, Lichius L, Kiljan M, Gozum G, Caiaffa MI, Cai J, Niu LN, Herter JM, Grüll H, Büttner R, Beleggia F, Bosco G, George J, Herter-Sprie GS, Reinhardt HC, Bozek K. Imaging mass cytometry dataset of small-cell lung cancer tumors and tumor microenvironments. BMC Res Notes. 2025 Sep 8;18(1):385. doi: 10.1186/s13104-025-07460-4. PMID: 40922010; PMCID: PMC12418687.

Kelepouras K, Saggau J, Bonasera D, Kiefer C, Locci F, Rakhsh-Khorshid H, Grauvogel L, Varanda AB, Peifer M, Loricchio E, Montinaro A, Croon M, Trifunovic A, Prencipe G, Insalaco A, De Benedetti F, Walczak H, Liccardi G. STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD. Nature. 2025 Aug 20. doi: 10.1038/s41586-025-09536-4. Epub ahead of print. PMID: 40834903.

Hunold P, Pizzolato G, Heramvand N, Kaiser L, Barbiera G, van Ray O, Thomas R, George J, Peifer M, Hänsel-Hertsch R. DynaTag for efficient mapping of transcription factors in low-input samples and at single-cell resolution. Nat Commun. 2025 Jul 28;16(1):6585. doi: 10.1038/s41467-025-61797-9. PMID: 40721574; PMCID: PMC12304361.

Pisula JI, Helbig D, Sancéré L, Persa OD, Bürger C, Fröhlich A, Lorenz C, Bingmann S, Niebel D, Drexler K, Landsberg J, Thomas R, Bozek K, Brägelmann J. Explainable, federated deep learning model predicts disease progression risk of cutaneous squamous cell carcinoma. NPJ Precis Oncol. 2025 Jun 28;9(1):205. doi: 10.1038/s41698-025-00997-4. PMID: 40581685; PMCID: PMC12206231.

Stahl D, Gödel P, Balke-Want H, Gholamipoorfard R, Segbers P, Tetenborg L, Koker M, Dörr J, Gregor L, Bachurski D, Rose F, Simon AG, Good Z, Jakob J, Häupl B, Nill M, Flümann R, Riet T, Lange D, Blakemore SJ, Baurmann H, Voltin CA, Potter N, Schlözer L, Freihammer M, Wagener-Ryczek S, Iuga AI, Heger JM, Ludwig H, Schleifenbaum JK, Propp J, Bröckelmann PJ, Jachimowicz RD, Knittel G, Borchmann S, Merkelbach-Bruse S, Pallasch C, Peifer M, Rybniker J, Quaas A, Nitz M, Brägelmann J, Müller W, Persigehl T, Bozek K, Theobald SJ, Büttner R, Oellerich T, Hallek M, Kobold S, Chmielewski M, Reinhardt HC, Mackall C, Abedpour N, Borchmann P, Ullrich RT. CSF1R⁺ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma. Cancer Cell. 2025 Jun 10:S1535-6108(25)00222-3. doi: 10.1016/j.ccell.2025.05.013. Epub ahead of print. PMID: 40513575.

Gewalt T, Dmitrieva AM, Elsner F, Zhao X, Sieber DD, Kocak IG, Yang Q, Orschel CV, Eckert NM, Goebel B, Nill M, Peter F, Hartmann A, Beleggia F, Odenthal M, Reinhardt HC, Ullrich RT, Graw F, Meder L. TAT-CRE inhalation enables tumor induction corresponding to adenoviral Cre-recombinase in a lung cancer mouse model. Commun Biol. 2025 May 13;8(1):741. doi: 10.1038/s42003-025-08146-0. PMID: 40360735; PMCID: PMC12075843.

Stachura P, Lu Z, Kronberg RM, Xu HC, Liu W, Tu JW, Schaal K, Kameri E, Picard D, von Karstedt S, Fischer U, Bhatia S, Lang PA, Borkhardt A, Pandyra AA. Deep transfer learning approach for automated cell death classification reveals novel ferroptosis-inducing agents in subsets of B-ALL. Cell Death Dis. 2025 May 18;16(1):396. doi: 10.1038/s41419-025-07704-y. PMID: 40382332; PMCID: PMC12085637.

Spindler J, Pandolfo F, Koch AE, Piccirillo P, Bihler J, Morgenstern M, Buschbaum S, Coon J, Hänsel-Hertsch R, Mehta KPM, Panier S. SLX4IP acts in parallel to FANCM to limit BLM-dependent replication stress at ALT telomeres. bioRxiv [Preprint]. 2025 May 29:2025.05.28.656696. doi: 10.1101/2025.05.28.656696. PMID: 40501906; PMCID: PMC12154878.

Roeck BF, Lotfipour Nasudivar S, Vorndran MRH, Schueller L, Yapici FI, Rübsam M, von Karstedt S, Niessen CM, Garcia-Saez AJ. Ferroptosis spreads to neighboring cells via plasma membrane contacts. Nat Commun. 2025 Mar 26;16(1):2951. doi: 10.1038/s41467-025-58175-w. PMID: 40140422; PMCID: PMC11947162.

Simonis A, Theobald SJ, Koch AE, Mummadavarapu R, Mudler JM, Pouikli A, Göbel U, Acton R, Winter S, Albus A, Holzmann D, Albert MC, Hallek M, Walczak H, Ulas T, Koch M, Tessarz P, Hänsel-Hertsch R, Rybniker J. Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages. Mol Syst Biol. 2025 Apr;21(4):341-360. doi: 10.1038/s44320-025-00093-6. Epub 2025 Mar 25. PMID: 40133533; PMCID: PMC11965535.

Yapici FI, Seidel E, Dahlhaus A, Weber J, Schmidt C, de Britto Chaves Filho A, Yang M, Nenchova M, Güngör E, Stroh J, Kotouza I, Beck J, Abdallah AT, Lackmann JW, Bebber CM, Androulidaki A, Kreuzaler P, Schulze A, Frezza C, von Karstedt S. An atlas of ferroptosis-induced secretomes. Cell Death Differ. 2025 Apr 25. doi: 10.1038/s41418-025-01517-4. Epub ahead of print. PMID: 40281125.

Frobel J, Hänsel-Hertsch R. The age-related decline of helicase function-how G-quadruplex structures promote genome instability. FEBS Lett. 2025 Jan;599(2):267-274. doi: 10.1002/1873-3468.14939. Epub 2024 May 27. PMID: 38803008; PMCID: PMC11771695.

Pedrera L, Prieto Clemente L, Dahlhaus A, Lotfipour Nasudivar S, Tishina S, Olmo González D, Stroh J, Yapici FI, Singh RP, Grotehans N, Langer T, García-Sáez AJ, von Karstedt S. Ferroptosis triggers mitochondrial fragmentation via Drp1 activation. Cell Death Dis. 2025 Jan 25;16(1):40. doi: 10.1038/s41419-024-07312-2. PMID: 39863602; PMCID: PMC11762985.

Ibruli O, Rose F, Beleggia F, Schmitt A, Cartolano M, Fernandez LT, Saggau J, Bonasera D, Kiljan M, Gozum G, Lichius L, Cai J, Niu LN, Caiaffa MI, Herter JM, Walczak H, Liccardi G, Grüll H, Büttner R, Bosco G, George J, Thomas RK, Bozek K, Reinhardt HC, Herter-Sprie GS. A novel mouse model recapitulating the MMR-defective SCLC subtype uncovers an actionable sensitivity to immune checkpoint blockade. J Cancer Res Clin Oncol. 2024 Nov 14;150(11):496. doi: 10.1007/s00432-024-05942-9. PMID: 39542886; PMCID: PMC11564195.

Kreten F, Büttner R, Peifer M, Harder C, Hillmer AM, Abedpour N, Bovier A, Tolkach Y. Tumor architecture and emergence of strong genetic alterations are bottlenecks for clonal evolution in primary prostate cancer. Cell Syst. 2024 Nov 20;15(11):1061-1074.e7. doi: 10.1016/j.cels.2024.10.005. Epub 2024 Nov 13. PMID: 39541986.

Werr L, Bartenhagen C, Rosswog C, Cartolano M, Voegele C, Sexton-Oates A, Di Genova A, Ernst A, Kahlert Y, Hemstedt N, Höppner S, Mansuet Lupo A, Pelosi G, Brcic L, Papotti M, George J, Bosco G, Quaas A, Tang LH, Robzyk K, Kadota K, Roh MS, Fanaroff RE, Falcon CJ, Büttner R, Lantuejoul S, Rekhtman N, Rudin CM, Travis WD, Alcala N, Fernandez-Cuesta L, Foll M, Peifer M, Thomas RK, Fischer M; Lung NEN Network. TERT Expression and Clinical Outcome in Pulmonary Carcinoids. J Clin Oncol. 2025 Jan 10;43(2):214-225. doi: 10.1200/JCO.23.02708. Epub 2024 Sep 30. PMID: 39348606; PMCID: PMC11709002.

Yapici FI, Bebber CM, von Karstedt S. A guide to ferroptosis in cancer. Mol Oncol. 2024 Jun;18(6):1378-1396. doi: 10.1002/1878-0261.13649. Epub 2024 Apr 8. PMID: 38590214; PMCID: PMC11161738.

Benard EL, Küçükaylak I, Hatzold J, Berendes KUW, Carney TJ, Beleggia F, Hammerschmidt M. wnt10a is required for zebrafish median fin fold maintenance and adult unpaired fin metamorphosis. Dev Dyn. 2024 Jun;253(6):566-592. doi: 10.1002/dvdy.672. Epub 2023 Oct 23. PMID: 37870737; PMCID: PMC11035493.

Darguzyte M, Antczak P, Bachurski D, Hoelker P, Abedpour N, Gholamipoorfard R, Schlößer HA, Wennhold K, Thelen M, Garcia-Marquez MA, Koenig J, Schneider A, Braun T, Klawonn F, Damrat M, Rahman M, Kleid JM, Theobald SJ, Bauer E, von Kaisenberg C, Talbot SR, Shultz LD, Soper B, Stripecke R. Long-Term Human Immune Reconstitution, T-Cell Development, and Immune Reactivity in Mice Lacking the Murine Major Histocompatibility Complex: Validation with Cellular and Gene Expression Profiles. Cells. 2024 Oct 12;13(20):1686. doi: 10.3390/cells13201686. PMID: 39451205; PMCID: PMC11506606.

Sauer PV, Pavlenko E, Cookis T, Zirden LC, Renn J, Singhal A, Hunold P, Hoehne-Wiechmann MN, van Ray O, Kaschani F, Kaiser M, Hänsel-Hertsch R, Sanbonmatsu KY, Nogales E, Poepsel S. Activation of automethylated PRC2 by dimerization on chromatin. Mol Cell. 2024 Oct 17;84(20):3885-3898.e8. doi: 10.1016/j.molcel.2024.08.025. Epub 2024 Sep 19. PMID: 39303719; PMCID: PMC11980035.

Berndt C, Alborzinia H, Amen VS, Ayton S, Barayeu U, Bartelt A, Bayir H, Bebber CM, Birsoy K, Böttcher JP, Brabletz S, Brabletz T, Brown AR, Brüne B, Bulli G, Bruneau A, Chen Q, DeNicola GM, Dick TP, Distéfano A, Dixon SJ, Engler JB, Esser-von Bieren J, Fedorova M, Friedmann Angeli JP, Friese MA, Fuhrmann DC, García-Sáez AJ, Garbowicz K, Götz M, Gu W, Hammerich L, Hassannia B, Jiang X, Jeridi A, Kang YP, Kagan VE, Konrad DB, Kotschi S, Lei P, Le Tertre M, Lev S, Liang D, Linkermann A, Lohr C, Lorenz S, Luedde T, Methner A, Michalke B, Milton AV, Min J, Mishima E, Müller S, Motohashi H, Muckenthaler MU, Murakami S, Olzmann JA, Pagnussat G, Pan Z, Papagiannakopoulos T, Pedrera Puentes L, Pratt DA, Proneth B, Ramsauer L, Rodriguez R, Saito Y, Schmidt F, Schmitt C, Schulze A, Schwab A, Schwantes A, Soula M, Spitzlberger B, Stockwell BR, Thewes L, Thorn-Seshold O, Toyokuni S, Tonnus W, Trumpp A, Vandenabeele P, Vanden Berghe T, Venkataramani V, Vogel FCE, von Karstedt S, Wang F, Westermann F, Wientjens C, Wilhelm C, Wölk M, Wu K, Yang X, Yu F, Zou Y, Conrad M. Ferroptosis in health and disease. Redox Biol. 2024 Sep;75:103211. doi: 10.1016/j.redox.2024.103211. Epub 2024 May 30. PMID: 38908072; PMCID: PMC11253697.

Garcia-Marquez MA, Thelen M, Bauer E, Maas L, Wennhold K, Lehmann J, Keller D, Nikolić M, George J, Zander T, Schröder W, Müller P, Yazbeck AM, Bruns C, Thomas R, Gathof B, Quaas A, Peifer M, Hillmer AM, von Bergwelt-Baildon M, Schlößer HA. Germline homozygosity and allelic imbalance of HLA-I are common in esophagogastric adenocarcinoma and impair the repertoire of immunogenic peptides. J Immunother Cancer. 2024 Apr 17;12(4):e007268. doi: 10.1136/jitc-2023-007268. PMID: 38631707; PMCID: PMC11029431.

Flümann R, Hansen J, Meinel J, Pfeiffer P, Goldfarb Wittkopf H, Lütz A, Wirtz J, Möllmann M, Zhou T, Tabatabai A, Lohmann T, Jauch M, Beleggia F, Pelzer B, Ullrich F, Höfmann S, Arora A, Persigehl T, Büttner R, von Tresckow B, Klein S, Jachimowicz RD, Reinhardt HC, Knittel G. An inducible Cd79b mutation confers ibrutinib sensitivity in mouse models of Myd88-driven diffuse large B-cell lymphoma. Blood Adv. 2024 Mar 12;8(5):1063-1074. doi: 10.1182/bloodadvances.2023011213. PMID: 38060829; PMCID: PMC10907402.

George J, Maas L, Abedpour N, Cartolano M, Kaiser L, Fischer RN, Scheel AH, Weber JP, Hellmich M, Bosco G, Volz C, Mueller C, Dahmen I, John F, Alves CP, Werr L, Panse JP, Kirschner M, Engel-Riedel W, Jürgens J, Stoelben E, Brockmann M, Grau S, Sebastian M, Stratmann JA, Kern J, Hummel HD, Hegedüs B, Schuler M, Plönes T, Aigner C, Elter T, Toepelt K, Ko YD, Kurz S, Grohé C, Serke M, Höpker K, Hagmeyer L, Doerr F, Hekmath K, Strapatsas J, Kambartel KO, Chakupurakal G, Busch A, Bauernfeind FG, Griesinger F, Luers A, Dirks W, Wiewrodt R, Luecke A, Rodermann E, Diel A, Hagen V, Severin K, Ullrich RT, Reinhardt HC, Quaas A, Bogus M, Courts C, Nürnberg P, Becker K, Achter V, Büttner R, Wolf J, Peifer M, Thomas RK. Evolutionary trajectories of small cell lung cancer under therapy. Nature. 2024 Mar;627(8005):880-889. doi: 10.1038/s41586-024-07177-7. Epub 2024 Mar 13. PMID: 38480884; PMCID: PMC10972747.

Valdez Capuccino, L., Kleitke, T., Szokol, B., Svajda, L., Martin, F., Bonechi, F., Krekó, M., Azami, S., Montinaro, A., Wang, Y., Nikolov, V., Kaiser, L., Bonasera, D., Saggau, J., Scholz, T., Schmitt, A., Beleggia, F., Reinhardt, H. C., George, J., Liccardi, G., … Peltzer, N. (2024). CDK9 inhibition as an effective therapy for small cell lung cancer. Cell death & disease, 15(5), 345. doi: 10.1038/s41419-024-06724-4.  PMID: 38769311